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It is evident that we are ignorant of the causes of pandemics of influenza at irregular intervals, and their occurrence has never, so far We are still obliged to think of unknown factors; and I can repeat the admission of similar ignorance in regard to cerebro- spinal fever In epidemic times" strains make their appearance which possess greater virulent strains must be due to intermittent causes; and it is still necessary to assume the action of some unknown influence, telluric, climatic, or other, which becomes operative under conditions of which we remain ignorant." But although no satisfactory explanation is known of the causes exciting either the minor or the major epidemics of influenza, there can be no doubt that the movements of the recent war have been responsible on a large scale for its increased virulence: sporanox price in pakistan.

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